Table S1: Membrane electrical properties of dentate granule cells
Naive (n=36)
Sc shRNA (n=32)
TWIK-1 shRNA (n=30)
Resting membrane potential (mV)
-74.9 +/- 0.6
-77.3 +/- 1.2
-70.6 +/- 0.6*
Input resistance (MOhm)
185.8 +/- 7.2
213.8 +/- 9.5
231.78 +/-9.8
Firing threshold potential (mV)
-37.2 +/- 0.7
-38.3 +/- 1.0
-39.3 +/- 0.7
Number of Spikes (at 30pA)
1.7 +/- 0.6
1.9 +/- 0.5
7.2 +/- 1.0*
AP Amplitude (mV)
77.5 +/- 1.8
75.1 +/- 1.7
73.5 +/- 1.5
Rheobase Current (pA)
42.4
42.8
26.4*
Data included from Rheobase measurements from Figure 3 regarding intrinsic excitability. Data are expressed as mean ± S.E.M (naïve, n=36; ScshRNA, n=32; TWIK-1 shRNA,n = 30). P values were calculated using the Student’s unpaired or paired t-test. * indicates P